| 董建国 1
，饶 丹 1
，覃燕灵 2，王艳午 2，张 宁 3，易本驰 1
，黄 立 1
，刘纪成 1
，邓凯伟 1.猪德尔塔冠状病毒研究进展[J].广东农业科学,2019,46(3):113-118 |
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猪德尔塔冠状病毒研究进展 |
| Research Progress on Porcine Deltacoronavirus |
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| DOI：10.16768/j.issn.1004-874X.2019.03.018 |
| 中文关键词: 猪德尔塔冠状病毒 基因组 病原学 进化分析 防控 |
| 英文关键词: porcine Deltacoronavirus genome etiology evolutionary analysis prevention and control |
| 基金项目:河南省科技攻关项目（182102110037）；河南省规模猪场重大疫病净化创新型科技团队项目；信阳农林学院重点学科培育学科预防兽医学（ZDXK201702）；信阳农林学院青年基金项目（201701005） |
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| 摘要点击次数: 2017 |
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| 中文摘要: |
| 猪德尔塔冠状病毒（Porcine Deltacoronavirus，PDCoV）为 δ 冠状病毒成员，是 2012 年新发现的
一种感染猪的冠状病毒，临床特征是引起母猪和仔猪腹泻症状，以呕吐、水样腹泻、脱水和食欲下降为基本特征，
发病仔猪中的死亡率为 30%~40%。该病于 2014 年在美国猪场爆发，同年在我国内陆爆发，随后几年该病已经
蔓延至世界上许多国家和地区，给养殖业带来了巨大的经济损失。目前针对 PDCoV 已经建立了一系列检测方法，
检测结果显示 PDCoV 既存在单独感染，也存在与其他猪肠道冠状病毒混合感染情况，然而目前针对 PDCoV 的
致病机制研究较少，对该病的认识不够全面，仍没有有效疫苗防控该病的发生。综述了 PDCoV 基因组特征、
蛋白功能、流行病学、遗传进化分析、检测方法及防控措施等方面的研究现状，以期为 PDCoV 致病机制研究
和临床研究提供借鉴。 |
| 英文摘要: |
| Porcine Deltacoronavirus (PDCoV) is a member of the δ-coronavirus, a newly discovered coronavirus
in 2012 which can infect porcine. Such coronavirus is clinically characterized by diarrhea symptoms in sows and piglets
and basically characterized by vomiting, watery diarrhea, dehydration and loss of appetite. The mortality rate of the
infected piglets is 30%-40%. The disease outbroke in the United States in 2014. The disease emerged in our country in
the same year and has spread to many countries and regions in the following years, which brought huge economic losses
to pig industry. At present, a series of test methods have been established for PDCoV infection, test results showed that
PDCoV not only infected pigs alone but also mixed with other porcine intestinal coronavirus to infect pigs. However, up
to now, there are few researches on the pathogenic mechanism of PDCoV and the understanding of the disease is not
comprehensive enough. There is still no effective vaccine for preventing and controlling the emergence of the disease.
In this paper, the current research status of PDCoV genome characteristics, protein function, epidemiology, genetic and
evolutionary analysis, detection methods and prevention and control measures were summarized so as to provide reference
for the study of pathogenic mechanism and clinical research of PDCoV. |
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