| 石倩、谢林香、陈立志、胡开辉、张燎原.17种中草药细菌群体感应抑制剂的筛选[J].广东农业科学,2014,41(10):77-80 |
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17种中草药细菌群体感应抑制剂的筛选 |
| Screening of quorum-sensing inhibitors from17 kinds of Chinese herbal medicine |
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| DOI： |
| 中文关键词: 中草药 群体感应 群体感应抑制剂 浮游迁移 |
| 英文关键词: Chinese herbal medicine quorum-sensing quorum-sensing inhibitors swarming mobility |
| 基金项目:国家自然科学基金（31301858）；教育部博士点基
金（20133515120011） |
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| 摘要点击次数: 1443 |
| 全文下载次数: 582 |
| 中文摘要: |
| 微生物致病性在很大程度上受到群体感应系统的调控、筛选群体感应系统抑制剂被认为是解决微生物
致病性的有效方法之一。对17 种中草药进行了群体感应抑制剂的筛选、结果表明、其中8 种中草药能抑制
Chromobacterium violaceum CV026 产紫色色素的能力。试管梯度试验表明、这8 种中草药有明显的群体感应抑制效
果。浮游抑制试验结果表明、17 种中草药中的13 种可抑制铜绿假单胞菌的浮游。进一步对中草药中群体感应抑制剂
的分离鉴定、将为揭示细菌群体感应抑制剂的机制研究和应用奠定基础。 |
| 英文摘要: |
| The pathogenicity of pathogen microorganism is regulated partially by microbial quorum sensing (QS),while
the screening of QS inhibitors (QSIs) is regard as an effective strategy to solve pathogen microorganism. In this study, 17
kinds of herbs were screened for QSIs, the results showed that Chromobacterium violaceum CV026 was suppressed by 8 of
these herbs. The tubes gradient tests showed that 8 of the 17 samples had significant inhibitory effects of quorum sensing.
Planktonic inhibition test results showed that Pseudomonas aeruginosa planktonic could be inhibited by 13 kinds of
Chinese herbal medicine. Isolation and identification of specific substances from these Chinese herbal medicine would
provide a basis for revealing their anti-QS mechanism. |
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