| 黄晓霞1，黄旭琳1，胡 坤2.负载姜黄素的玉米醇溶蛋白-果胶纳米
颗粒制备及抗氧化活性研究[J].广东农业科学,2015,42(18):88-92 |
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负载姜黄素的玉米醇溶蛋白-果胶纳米
颗粒制备及抗氧化活性研究 |
| Preparation and antioxidant activity of zein/pectinnanoparticles loading curcumin |
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| DOI： |
| 中文关键词: 姜黄素 玉米醇溶蛋白 果胶 纳米颗粒 抗氧化活性 |
| 英文关键词: curcumin zein pectin nanopaticles antioxidant activity |
| 基金项目: |
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| 摘要点击次数: 1588 |
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| 中文摘要: |
| 以反溶剂法制备负载姜黄素的玉米醇溶蛋白纳米颗粒，并以静电沉积法使果胶多糖吸附到纳米
颗粒表面形成核/ 壳型复合纳米颗粒。研究果胶浓度、pH 值对纳米颗粒稳定性的影响及纳米颗粒的储存稳定
性，并比较纳米颗粒包埋的姜黄素与游离姜黄素的抗氧化活性。结果表明，当胶体分散液中果胶浓度为0.11%
时，能形成稳定的胶体纳米颗粒；胶体颗粒在酸性和中性pH 条件下非常稳定，平均粒径小于250 nm，而在pH
6~6.5 时，粒径较大（d >300 nm）；胶体颗粒分散液经常温储存1 个月后仍非常稳定。纳米颗粒包埋的姜黄素
具有较强的抗氧化活性，其总抗氧化能力约为姜黄素乙醇溶液的2 倍。 |
| 英文摘要: |
| Zein nanoparticles loading curcumin were synthetized with anti-solvent method，and the
particles were further coated with pectin by electrostatic deposition to form zein core/pectin shell nanoparticles.
The effects of pectin concentration and pH on nanoparticle suspension stability were investigated. The
long term storage stability of particle suspension and the antioxidant activity of loaded curcumin were also
determined. The results showed that stable nanoparticles formed when the pectin concentration in colloidal
suspension was 0.11%. The nanoparticles were very stable at acid and neutral pH with the average particle
size lower than 250 nm，but the average particle size increased to higher than 300 nm at pH 6.0-6.5. The
particle suspension was very stable after 1 month storage at room temperature. The encapsulated curcumin in
nanoparticles exhibited strong antioxidant activity and the total antioxidant capacity was two times higher than
that of free curcumin solubilized in ethanol. |
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