文章摘要
周 芳,孙铭阳,梅 瑜,顾 艳,徐世强,李静宇,蔡时可,王继华.药用植物穿心莲研究进展[J].广东农业科学,2021,48(1):9-16
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Research Progress in the Medicinal Plant Andrographis paniculate
  
DOI:10.16768/j.issn.1004-874X.2020.07.002
中文关键词: 穿心莲  代谢成分  药理活性  种质创新  基因组学
英文关键词: Andrographis paniculate  metabolic composition  pharmacological activity  germplasm innovation  genomics
基金项目:广东省农业科学院科技创新战略专项资金(高水平农科院建设)- 人才项目(R2019PY-JX003); 广东省重点领域研发计划项目(2020B020221001);广东省现代农业产业技术体系创新团队项目(2019KJ148)
作者单位
周 芳,孙铭阳,梅 瑜,顾 艳,徐世强,李静宇,蔡时可,王继华 广东省农业科学院作物研究所 / 广东省农作物遗传改良重点实验室广东 广州 510640 
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中文摘要:
      穿心莲为传统大宗中药材,爵床科,以地上部分入药,可抗菌和抗病毒,主要产自我国华南地区, 是规模化种植水平较高的南药品种之一。穿心莲体内发挥主要药效的化合物为二萜类内酯和黄酮类物质,二者 也是多种中成药的原料之一,可作为兽药的主要成分。穿心莲的临床作用为保肝利胆、清热解毒和抗菌消炎等, 有“中药抗生素”之称。学者对穿心莲的研究大多集中在其体内二萜类内酯的药理活性上。随基因组数据库的 成功注释,其药用成分生成等内在分子机理的相关研究将得以顺利开展。穿心莲品质不稳定,体内有效活性成 分含量受品种、产地、栽培技术、收获时间和加工技术等多方面因素影响。作为一类植物源抗生素,规范化种 植穿心莲带来的应用前景将十分广阔。从穿心莲的药理活性、活性成分代谢、种质资源评价、创新与利用等方 面进行总结,以期为后续有关穿心莲的开发利用提供参考。
英文摘要:
      Andrographis paniculata (Burm. F.) Nees in Acanthaceae, is a traditional Chinese medicinal material. It is used as medicine from the ground part, which can be antibacterial and antiviral. It is mainly produced in southern China and is one of the varieties of southern medicine with a high level of large-scale planting. The main medicinal compounds in A. paniculata are diterpene lactones and flavonoids, which are also the raw materials of many Chinese patent medicines and can be used as the main components of veterinary drugs. The clinical effects of A. paniculata include protecting the liver and promoting choleretics, clearing away heat and detoxification, anti-bacterial, and anti-inflammatory, and it is called “antibiotic of Chinese medicine”. In the past, researches on A. paniculata mostly focused on the pharmacological activity of diterpene lactones. With the successful annotation of the genome database, related researches on the internal molecular mechanism such as the generation of its medicinal ingredients will be carried out smoothly. The quality of A. paniculata is unstable, and the contents of effective active ingredients are affected by many factors such as variety, place of production, cultivation technology, harvest time and processing technology. As a class of plant-derived antibiotics, the application prospects brought by standardized planting of A. paniculata will be broad. This article summarizes the research on the pharmacological activity, active ingredient metabolism, germplasm resource evaluation, innovation and utilization of A. paniculata, soas to provide references for the development and utilization of A. paniculata.
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