| 李蔚 董传甫.蛙病毒的转录组和蛋白质组分析研究进展[J].广东农业科学,2014,41(1):127-131 |
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蛙病毒的转录组和蛋白质组分析研究进展 |
| Research progress of transcriptomic andproteomic analysis in Ranavirus |
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| DOI： |
| 中文关键词: 蛙病毒 转录组学分析 蛋白质组学分析 |
| 英文关键词: Ranavirus transcriptomic analysis proteomic analysis |
| 基金项目: |
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| 摘要点击次数: 2373 |
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| 中文摘要: |
| 蛙病毒属是一群大型的胞浆型DNA 病毒属虹彩病毒科能导致包括鱼类、两栖类和爬行类等冷血动
物产生严重疾病,蛙病毒分子生物学研究是阐明病毒复制,疾病产生各种相关因子作用机制的基础,微阵列分析技
术,蛋白和DNA 复制抑制下的转录产物分析,质谱蛋白质组学等分子生物学技术已被广泛应用于分析蛙病毒的基
因转录和蛋白表达多种蛙病毒转录组和蛋白质组分析使人们能够了解这一类病毒基因的转录产物转录时相病
毒蛋白表达的整体状态功能结构和可能的调控方式. |
| 英文摘要: |
| Ranavirus genus of Iridoviridae family is a member of the nucleocytoplasmic large DNA viruses (NCLDV). It is
one of the infectious viral pathogens associated with severe disease in cold-blooded vertebrates, including fish, amphibians
and reptiles. The study on molecular biology of ranavirus has provided insights into viral replication, intrinsic and extrinsic
factors contributed to disease outbreaks. Transcriptomic and proteomic analysis including the oligonucleotide microarray, the
temporal class of the gene expression under drug inhibition assay and mass spectrometry (MS) proteomic methods have been
applied to identify structure, function and regulation of all transcripts and proteins of ranavirus |
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