| 马李一，王有琼，张重权，马金菊，段琼芬.响应曲面优化超临界CO2萃取印楝素A工艺研究[J].广东农业科学,2014,41(19):94-98 |
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响应曲面优化超临界CO2萃取印楝素A工艺研究 |
| Optimization of supercritical CO2 extraction of azadirachtin A by response surface methodology |
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| DOI： |
| 中文关键词: 印楝素A 超临界 响应曲面法 萃取 夹带剂 |
| 英文关键词: Azadirachtin A supercritical response surface methodology extraction entrainer |
| 基金项目:国家“十二五”科技支撑计划项目（2012BAD21B0404） |
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| 摘要点击次数: 1478 |
| 全文下载次数: 535 |
| 中文摘要: |
| 运用响应曲面设计（Box-Behnken0优化超临界CO2萃取印楝素A 提取工艺。在单因素试验基础上，以温度、压力、夹带剂用量为响应变量，印楝素A 质量分数为响应值进行优化，模拟得到萃取印楝素A 的二次多项回归方程模型：Y=0.3+0.067A+0.02B+0.043C+0.016AB-0.006AC+0.03BC-0.008A2+0.014B2-0.03C2，模型P<0.01，达到极显著水平；模型确定系数R平方=0.9705，说明该模型与实际试验拟合较好。响应曲面分析法优选结果表明，超临界CO2萃取印楝素A 的最佳工艺条件为萃取温度40℃、萃取压力28.65 MPa、萃取时间2 h，夹带剂用量2.79%，印楝素A 实测结
果0.40%与响应曲面拟合所得方程预测值0.42%吻合较好。采用响应曲面法建立的印楝素A 提取工艺模型能很好地预测试验结果。 |
| 英文摘要: |
| Supercritical CO2 extraction technology on azadirachtin A from neem kernels was optimized by Box -Behnken center composite design. Taking extraction temperature, extraction pressure and entrainer dose as response variables, and azadirachin A (mass fraction) as response values, the extraction process was optimized by the method of response surface methodology and based on single-factor experiments and Box-Behnken central composite experimental design. The quadratic regression model for the extraction azadirachin A was as follows: Y=0.3+0.067A+0.02B+0.043C+0.016AB -0.006AC +0.03BC -0.008A2 +0.014B2 -0.03C2. The R2 was 0.9705, and P <0.01, reaching the level of verysignificance, demonstrating that the equation being well regression. The results showed that the optimal process conditions of supercritical CO2 extraction extracting azadirachtin A by response surface methodology were as follows: extraction temperature 40益, extraction pressure 28.36 MPa and entrainer dose 2.79%; Under these conditions, the practical value of azadirachtin A was 0.40%, which agreed well with the predicted value of 0.42%. So extraction model of azadirachtin A established by Box- Behnken method precisely predicted the experiment results. |
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