| 周丽萍，陈雪香，刘晓娟，等.山莓叶抑制家兔离体肠管运动活性物的分离纯化及活性研究[J].广东农业科学,2015,42(11):108-112 |
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山莓叶抑制家兔离体肠管运动活性物的分离纯化及活性研究 |
| Isolation，purification and activity of active componentsfrom Rubus corchorifolius leaves and their inhibitioneffects on movement of isolated rabbit intestinal |
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| DOI： |
| 中文关键词: 山莓叶 离体肠 分离纯化 对羟基肉桂酸乙酯 |
| 英文关键词: Rubus corchorifolius leaves isolated intestinal from rabbit isolation and purification P-hydroxy ethyl cinnamate |
| 基金项目: |
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| 摘要点击次数: 1248 |
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| 中文摘要: |
| 为明确山莓叶中抗腹泻的药效成分，利用溶剂萃取、常压柱层析、中压柱层析对山莓叶中的活性成分
进行分离纯化，采用家兔离体肠实验检测抗腹泻活性，并对活性单体进行结构鉴定。结果表明：山莓叶中抑制离
体肠效果好的化合物是对羟基肉桂酸乙酯，当其浓度为20 mg/mL 时，离体肠张力增量的变化率达到70.0%，强于
阿托品的抑制效果。 |
| 英文摘要: |
| In order to ensure the anti-diarrhea components from Rubus corchorifolius leaves，the active componentsfrom R. corchorifolius leaves were isolated and purified using solvent extraction，column chromatography and middlepressure column chromatography，and their anti-diarrhea activities were determined through the movement of isolatedintestinal of rabbit，meanwhile，the structure of active monomer was identified. The results showed that the componentwhich had anti-diarrhea activity on isolated intestinal was P-hydroxy ethyl cinnamate in R. corchorifolius leaves，whenthe concentration was 20 mg/mL，the change rate of tension increment of isolated intestinal reached 70.0%，and itsinhibition effect was better than that of atropine. |
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