| 张云波，刘华忠，谷毅鹏，等.乌贼墨多糖对环磷酰胺介导小鼠卵巢氧化应激损伤的干预效应[J].广东农业科学,2015,42(14):90-93 |
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乌贼墨多糖对环磷酰胺介导小鼠卵巢氧化应激损伤的干预效应 |
| Intervention effects of sepia ink polysaccharideson ovarian oxidative stress injury in micemediated by cyclophosphamide |
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| DOI： |
| 中文关键词: 乌贼墨多糖渊SIPS冤 卵巢 抗氧化 免疫 |
| 英文关键词: sepia ink polysaccharides (SIPS) ovary antioxidant immune |
| 基金项目: |
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| 摘要点击次数: 1444 |
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| 中文摘要: |
| 为了探究乌贼墨多糖（sepia ink polysaccharides, SIPS）对小鼠卵巢氧化应激和免疫能力的影响，将
60 只KM 雌性小鼠随机分为正常组、模型组、治疗1 组、治疗2 组、治疗3 组、治疗4 组等6 组。腹腔注射环磷
酰胺（cyclophoshamide, CP）造模，正常组注射生理盐水，口服灌胃SIPS 或生理盐水，观测各组小鼠体重变化、器
官指数、卵巢丙二醛（MDA）含量和超氧化物歧化酶（SOD）活性变化。结果表明：每只灌胃80 mg/kg SIP 为多糖
最佳剂量，与模型组相比，80 mg/kg 处理能显著降低卵巢MDA 含量、提高SOD 活性，提高卵巢指数、胸腺指数、
脾脏指数，增强小鼠卵巢抗氧化能力及免疫力。 |
| 英文摘要: |
| To explore the effects of sepia ink polysaccharides (SIPS) on ovarian oxidative stress and immune
ability of mice, 60 KM female mice were randomly divided into 6 groups: normal group (CON), model group (CP),
treatment groups 1 to 4 (SIP+CP:1-4). Mice injury model was built by intraperitoneal injection of cyclophosphamide,
mice of normal group were injected with saline. Mice were oral administration of SIPS or saline. Then the weight
changes, organ index of mice and ovarian MDA content and SOD activity were detected. The results showed that, 80
mg/kg SIPS per mouse was the optimal dose. Compared with the model group, 80 mg/kg SIPS could significantly
reduce the ovarian MDA content and significantly improve the ovarian SOD activity, improve the ovarian index,
thymus index and spleen index, intensify anti-oxidative function in ovary and the body immunity of mice. |
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