| 吴幕绵,陈舒婷,李涛,等.青枯菌效应蛋白调控植物免疫研究进展[J].广东农业科学,2024,(8-10):- |
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青枯菌效应蛋白调控植物免疫研究进展 |
| Research progress on the role of effector proteins in the pathogenesis of Ralstonia solanacearum and the regulation of immune mechanisms |
| 投稿时间：2024-05-20 修订日期：2024-07-13 |
| DOI： |
| 中文关键词: 青枯菌 青枯病 三型分泌系统 效应蛋白 免疫反应 蛋白质互作 |
| 英文关键词: Ralstonia solanacearum bacterial wilt Type III secretion system effectors immune response protein-protein interaction |
| 基金项目:国家自然科学基金面上项目(32372702)；省级乡村振兴战略专项资金种业振兴项目(2022-NPY-00-025)；广东省农业科学院科技创新战略专项资金(高水平农科院建设)-人才项目(R2023PY-JX008)；广州市科技计划项目(202201010247)。 |
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| 中文摘要: |
| 青枯菌(Ralstonia solanacearum)通过寄主植物的根部侵染维管束系统,造成植物产生不可逆的萎蔫,直至死亡。青枯菌侵染植物引起的青枯病(Bacterial wilt)是一种毁灭性土传细菌病害,目前已成为制约我国茄科作物生产的主要病害之一。Ⅲ型分泌系统(Type III secretion system, T3SS)是青枯菌侵染寄主过程中的决定性致病因子,青枯菌利用T3SS向寄主细胞中注射大量效应蛋白(Type III effectors, T3Es)来干扰寄主的免疫反应。国内外学者致力于探索青枯菌是如何通过识别寄主体内的靶标蛋白来干扰宿主细胞过程,调控寄主免疫功能。因此,青枯菌T3Es靶向识别的植物蛋白的鉴定有助于了解青枯菌T3Es的生物学功能、青枯菌的致病过程,同时也有助于挖掘寄主中青枯病抗性相关蛋白及其作用机制。迄今为止,尽管大多数T3Es功能仍然未知,但目前已报道的青枯菌T3Es可以通过多种分子机制干扰植物先天免疫、诱导植物发生超敏反应、影响植物的代谢和激素信号传导通路等来调节寄主抗青枯病能力。本文总结并讨论了目前关于青枯菌T3Es的特征、功能鉴定方法及其参与调控青枯菌致病性及植物免疫机制的研究进展,有助于更加深入地了解青枯菌T3Es的致病机理及寄主免疫系统的应答机理；在此基础上,对青枯菌T3Es与寄主互作机制研究进行展望,为青枯菌诱导寄主抗性机制的解析及青枯病的防治提供有效参考。 |
| 英文摘要: |
| R. solanacearum infects the vascular bundle system through the roots of host plants, causing irreversible wilting of plants. Bacterial wilt caused by R. solanacearum is a devastating soil-borne bacterial disease. At present, it has become one of the main diseases restricting the production of Solanaceae crops in China. Type III secretion system (T3SS) is a decisive pathogenic factor of R. solanacearum infecting, which uses T3SS to inject large amounts of Type III effectors (T3Es) into host cells to interfere with the immune response of the host. Scholars at home and abroad are committed to exploring how R. solanacearum interferes with host cell processes and regulates host immune function by identifying target proteins in the host. Therefore, the identification of host proteins that can be targeted by T3Es is helpful to understand the biological function of R.solanacearum T3Es, the pathogenic process of R.solanacearum, and to explore the R.solanacearum resistance-related proteins and their mechanism of action in hosts. So far, more and more T3Es have been reported to interfere with plant innate immunity, induce plant hypersensitive response, and affect plant metabolism and hormone signal transduction through a variety of molecular mechanisms to destroy the host cell process. In this review, we summarize and discuss the current research progress on the species complex T3Es of R. solanacearum, including the structural characteristics and functional identification methods of T3Es, and the functional mechanism of T3Es are summarized and discussed, which can provide a more in-depth understanding of the pathogenic mechanism of R. solanacearum T3Es. On this basis, future research and characterization of the functional mechanism of T3Es are prospected, which provides an effective reference for the analysis of the host resistance mechanism induced by R. solanacearum, and the prevention and treatment of R. solanacearum. |
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