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| Pharm acoki net i csand res i dueel i m i nat i on ofni aci nnorf l oxaci n prem i x i n M acr obr achi um r os enber gi i |
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| Abstract: |
| To det er mi ne t he par amet er s ofphar macoki net i cs and r esi due el i mi nat i on ofni aci n nor f l oxaci n pr emi x i n
M acr obr achi um r osenber gi i ,t he M .r osenber gi iwer e f ed wi t h ni aci n nor f l oxaci n pr emi x by or alper f usi on,t he t i ssue sampl es
wer e pur i f i ed by or gani c ext r act i on and sol i d phase ext r act i on.The concent r at i ons ofni aci n nor f l oxaci n wer e meas ur ed by
ul t r a per f or mance l i qui d chr omat ogr aphy ( UPLC) .The r esul t s showed t hat ,af t er M .r osenber gi iwer e or alper f used wi t h
ni aci n nor f l oxaci n pr emi x ( 20 mg/ kg body wei ght ) ,t he hepat opancr eas compl i ed phar macoki net i c t wo-compar t mentmodel
wi t h f i r stor derabsor pt i on.The mai n phar macoki net i c par amet er s wer e as f ol l ows:t he peak t i me ( T pea k )was 2. 905 h,t he
maxi mum peak concent r at i on ( C max )was328. 12 滋g/ mL,t he di st r i but i on hal f -l i f e ( T 1/ 2琢 )was2. 178 h,t he el i mi nat i on hal f -l i f e
( T 1/ 2茁 )was10. 058 h;and af t ercont i nuousor alper f usi on wi t h ni aci n nor f l oxaci n pr emi xes( 20 mg/ kg body wei ght )f or5 days,
dr ug r esi duest i me when i t sconcent r at i on l esst han 50 滋g/ kg i n hepat opancr eas,muscl e,bl ood t i ssue wer e 12 d,4 d,5 d,
r espect i vel y. |
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