| For t y mal e Bal b/ c mi ce wer e di vi ded i nt o t hr ee gr oups:exper i ment algr oups ( Panul i r us st i mpsonipr ot ei n
subgr oup and oval bumi n subgr oup) ,Coca爷s l i qui d negat i ve cont r olgr oup and bl ank gr oup.I mmuni zed by i nt r aper i t oneal
i nj ect i on ofP.st i mpsonipr ot ei nsoroval bumi n wi t h al umi num hydr oxi de,chal l enged by l avage wi t h t he same al l er gen,t he
f ood al l er gy mi ce wer e est abl i shed.The I gE and hi st ami ne i n ser um wer e measur ed by ELI SA.Number s ofi nf l ammat or y
cel l s and eosi nophi l s ( EOS) i n br onchoal veol ar l avage f l ui d ( BALF) wer e count ed. Lung t i ssues wer e obser ved f or
hi st ol ogi calal t er at i on i n l i ghtmi cr oscope.Sympt oms ( shi ver i ng,t achypnea,etal . )wer e pr esent ed i n exper i ment algr oup
mi ce af t erchal l enged wi t h al l er gens .Compar ed wi t h Coca爷sl i qui d gr oup orbl ank gr oup袁t he ser um I gE and hi st ami ne l evel
ofexper i ment algr oup i ncr eased s i gni f i cant l y.Number sofi nf l ammat or y cel l sofBALF i n P.st i mpsonipr ot ei n s ubgr oup and
oval bumi n subgr oup wer e 37. 5依3. 4,41. 2依4. 1 r espect i vel y,and number s ofEOS wer e 18依6,15依4,r espect i vel y.I nf i l t r at i on
ofi nf l ammat or y cel l s( l ymphocyt es,eosi nophi l s,macr ophages,etal . )i nt o mesenchymaland al veol us,t hi ckeni ng oft he wal l
oft er mi nalbr onchi ol e,and epi t hel i alcel l s br eak and sheddi ng,wer e obser ved evi dent l y i n t he pul monar y t i ssues oft he
mi ce i n P.st i mpsonipr ot ei n subgr oup and oval bumi n subgr oup.The r esul t si ncl i cat e t hatl ung i san or gan af f ect ed by f ood
al l er gy.I nf i l t r at i on ofi nf l ammat or y cel l s ( l ymphocyt es ,eosi nophi l s,macr ophages,etal .)i nt o mesenchymaland al veol usof
l ung may be t he i mmunol ogi calbasi sofast hma.Ther e i scer t ai n cor r el at i on bet ween f ood al l er gy and ast hma. |
