| Haemophilus parasuis（HPS）disease is a systemic inflammation caused by HPS infection in pigs,such as polyserositis, pneumonia, arthritis and meningitis. HPS is a Gram-negative, non-motile, pleomorphic rod-shaped and capsule bacterium, which is a conditional pathogenic bacterium in the upper respiratory tract of pigs. There are many serum types of HPS, and the virulence of each strain varies greatly. The virulence strains can infect any day-old pig and cause HPS disease. In recent years, HPS has been widely prevalent in China, and co-infection with a variety of viruses and bacteria is common. HPS infection has caused high morbidity and mortality of pigs and resulted in huge economic losses, which seriously affected the healthy development of pig industry in China. The etiologic characteristics, epidemiology, pathogenic mechanism and virulence factors of HPS were introduced, and the research progress in HPS laboratory diagnosis and development of vaccines such as inactivated vaccine, subunit vaccine and vaccine of bacterial ghost were summarized in order to provide references . |
