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| Effect of Chicken Coccidia Vaccine and Anticoccidial DrugsShuttle Program on the Drug Resistance of Coccidia |
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| DOI：10.16768/j.issn.1004-874X.2022.03.013 |
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| Abstract: |
| 【Objective】The study was carried out to investigate the effect of biological shuttle program using coccidia
vaccines and anticoccidial drugs on the drug resistance of chicken coccidia in broiler farms.【Method】Huadu isolates of
Eimeria tenella were isolated and identified from five chicken farms in Huadu District, and these farms have been using
coccidial vaccine and anti-coccidial drug shuttle program. Yingde isolates of E. tenella were isolated from five chicken farms
in Yinde City, and the five farms have been using only anti-coccidial drugs to control coccidiosis. The resistances of Huadu and
Yingde isolates to 6 anticoccidial drugs were tested respectively by using indicators including anticoccidial index (ACI), rate
of reduction in lesion score (RLS), percentage of optimum anticoccidial activity (POAA) and relative oocyst production (ROP).
【Result】The cecal tissue sections of chickens of the two challenged groups showed that the mucosal layer was extensively
affected with loss of intestinal glands, inflammatory cell infiltration, and many coccidial oocysts were found in the mucosa
and submucosa. The results of ACI showed that the Huadu isolates were resistant seriously to nicarbazine, clodipidine and
maduramycin, and moderately resistant to other 3 drugs; and the Yingde isolates were moderately resistant to all 6 drugs. The
results of POAA showed that the Huadu isolates were sensitive to the mixture of maduramycin and nicarbazine, but resistant
to other drugs, while the Yingde isolates were sensitive to all 6 drugs. The results of RLS and ROP showed that the two mixed
isolates were resistant to all 6 drugs. Based on comprehensive evaluation, the Huadu isolates were resistant moderately to
mixture of maduramycin and nicarbazine, and resistant seriously to other five drugs; while the Yingde isolates were resistant
moderately to all six drugs.【Conclusion】The field isolates of chicken coccidia were resistant to anticoccidial drugs at different
levels with multi-drug resistances. Both isolates from Huadu District and Yingde City showed resistance to six drugs moderately
or seriously, suggesting that biological shuttle program could not significantly restore sensitivity of E. tenella compared to
program using anticoccidial drugs only. |
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