| 黎桂玲，刘 科，黎雄才，邝少松，王 刚.不同生理阶段及性别 SPF 级 BALB/c 小鼠和 C57BL/6 小鼠血液生理生化指标测定与比较[J].广东农业科学,2019,46(12):102-109 |
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不同生理阶段及性别 SPF 级 BALB/c 小鼠和 C57BL/6 小鼠血液生理生化指标测定与比较 |
| Determination and Comparison of Blood Physiological and Biochemical Indexes Between SPF BALB/c Mice and C57BL/6Mice in Different Physiological Stages and Genders |
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| DOI：10.16768/j.issn.1004-874X.2019.12.014 |
| 中文关键词: BALB/c 小鼠 C57BL/6 小鼠 血常规 血生化 性成熟 体成熟 |
| 英文关键词: BALB/c mice C57BL/6 mice blood routine blood biochemical sexual maturity body maturity |
| 基金项目:广东省科技计划项目（2013B060300014） |
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| 中文摘要: |
| 【目的】 测定6周龄与9周龄BALB/c小鼠和C57BL/6小鼠的血常规、血生化值并进行比较分析。
【方法】用全自动血细胞分析仪、全自动生化分析仪分别测定血常规、血生化值。【结果】（1）相同生理阶
段的BALB/c异性小鼠血常规值中NE%、LY%差异极显著，不同生理阶段的同性小鼠LY%、HGB等8项指标差
异显著；相同生理阶段的C57BL/6异性小鼠血常规值中RBC、WBC等7项指标差异显著，不同生理阶段的同性
小鼠WBC、NE等6项指标差异显著。（2）6周龄BALB/c异性小鼠所有检测血生化指标差异不显著，随着生理
阶段的变化，AST、ALP等8项指标差异极显著，不同生理阶段的同性小鼠ALP、GLU等7项指标差异显著；相
同生理阶段的C57BL/6异性小鼠血生化指标差异不显著，不同生理阶段的同性小鼠ALP、GLU等7项指标差异显
著。（3）随着生理阶段的变化，BALB/c小鼠与C57BL/6小鼠血液生理生化部分指标差异性增大。【结论】生
理阶段、性别均对小鼠血液生理生化指标有显著性影响。 |
| 英文摘要: |
| 【Objective】The study was conducted to measure and compare the blood routine and blood biochemical
values of 6 weeks old and 9 weeks old BALB/c mice and C57BL/6 mice.【Methods】Blood routine and biochemical
values were determined by automatic blood cell analyzer and automatic biochemical analyzer.【Results】(1) There were
extremely significant differences in 2 blood physiological indicators(NE% and LY%) of heterosexual BALB/c mice at the
same physiological stage , and there were significant differences in 8 indicators (LY%, HGB and etc.) in homosexual mice
at different physiological stages. There were significant differences in 7 blood physiological indicators (RBC and WBC and
etc.) of heterosexual C57BL/6 mice at the same physiological stage, and there were significant differences in 6 indicators
(WBC and NE and etc.) of homosexual mice at different physiological stages. (2) There was no significant difference in
the biochemical indexes between the heterosexual 6 weeks old mice , with the changes of physiological stages, and there
were extremely significant differences in 8 blood biochemical indicators (AST, ALP and etc.). There was no significantdifference in the biochemical indexes of heterosexual C57BL/6 mice at the same physiological stage , but there were significant
differences in 7 blood biochemical indicators (ALP, GLU and etc.) . (3) With the changes of physiological stages, there was
an increase in the difference in part of blood physiological and biochemical indicators of BALB/c mice and C57BL/6 mice.
【Conclusions】The physiological and biochemical indexes of mice blood are significantly affected by the physiological stage
and gender of mice. |
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