| 孔亚茹，周小枫，熊浩铭，张 哲，张 豪，李加琪，袁晓龙.基质金属蛋白酶 MMP2 和 MMP9 在哺乳动物卵泡发育中的作用研究进展[J].广东农业科学,2020,47(3):103-110 |
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基质金属蛋白酶 MMP2 和 MMP9 在哺乳动物卵泡发育中的作用研究进展 |
| Research Progress in Effects of Matrix Metalloproteinases MMP2 and MMP 9 on Follicular Development in Mammals |
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| DOI：10.16768/j.issn.1004-874X.2020.03.014 |
| 中文关键词: 基质金属蛋白酶 明胶酶 MMP2 MMP9 细胞外基质 卵泡发育 哺乳动物 |
| 英文关键词: matrix metalloproteinases gelatinase MMP2 MMP9 extracellular matrix follicular development |
| 基金项目:国家生猪现代农业产业技术体系项目（CARS-35）；国家自然科学基金青年项目（31902131）；科技部科技性基础工作专项（2014FY120800）；广东省杨帆计划项目（2014YT02H042）；广东省普通高校青年创新人才项目（2018KQNCX019）；广东省科技创新专项（2018B020203003） |
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| 中文摘要: |
| 在哺乳动物卵泡发育过程中，卵泡腔的形成和扩张、排卵、黄体化以及闭锁等伴随明显的组织
重塑。卵泡膜细胞和颗粒细胞的细胞外基质及卵泡液中含有大量的明胶蛋白、纤维蛋白和Ⅳ型胶原蛋白等，
这些活性蛋白为卵泡膜细胞和颗粒细胞的迁移、增殖和分化提供了必要条件。基质金属蛋白酶 -2（matrix
metalloproteinases 2, MMP2）和酶 -9（MMP9）在其他 MMPs、雌激素、凋亡和自噬信号通路的协同作用下，分
解细胞外基质和卵泡液中的明胶蛋白、纤维蛋白和 IV 型胶原蛋白等，促进细胞凋亡和血管生成，使卵巢组织
发生降解和重塑，进而影响卵泡膜细胞和颗粒细胞的功能、卵泡腔的形成及扩张，调控卵泡的生长发育。针对
MMP2 和 MMP9 调节卵泡生长、排卵、黄体化及闭锁的研究进展进行综述。 |
| 英文摘要: |
| In mammalian follicular development, it is accompanied by significant tissue remodeling, which includes
follicular cavity formation and expansion, ovulation, luteinization and atresia. In the extracellular matrix（ECM）and
follicular fluid derived from follicular membrane cells and granulosa cells, there are abundant proteins such as gelatin
protein, fibrin and type Ⅳ collagen. These active proteins provide necessary conditions for the migration, proliferation and
differentiation of follicular membrane cells and granulosa cells. Under the coordination control of the other MMPs, estrogen,
apoptosis and autophagy signaling pathways, MMP2 and MMP9 decompose proteins such as gelatin protein, fibrin and type
Ⅳ collagen in extracellular matrix and follicular fluid, promote cell apoptosis and angiogenesis, degrade and reshape ovarian
tissues, and then affect the function of follicular membrane cells and granulosa cells, the formation and expansion of follicular
cavity, and regulate the growth and development of follicles. This paper mainly reviews the research progress of MMP2 and
MMP9 in regulation of follicular growth, ovulation, luteinization and atresia. |
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