| 张爱晶1 ，郭兴玉 2，何浩博 1 ，马博涵 1 ，李泽远 1 ，赵秋竹 1 ，刘明明 1 ，姚 丹 1.主要农作物 lncRNA 鉴定与分析研究进展[J].广东农业科学,2020,47(5):10- |
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主要农作物 lncRNA 鉴定与分析研究进展 |
| Research Progress on Identification and Analysis of lncRNA in Major Crops |
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| DOI：10.16768/j.issn.1004-874X.2020.05.001 |
| 中文关键词: 长链非编码 RNA 数据库 植物发育 表观遗传学 基因调控 生物学功能 |
| 英文关键词: lncRNAs database plant development epigenetics gene regulation biological function |
| 基金项目:1 |
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| 中文摘要: |
| 随着基因组和生物信息学技术的进步，特别是高通量测序技术的发展，人们发现了许多没有蛋白质编码潜力的转录单位。其中，长链非编码 RNA（long non-coding RNAs, lncRNAs）是一种长度大于 200 nt 的非编码 RNA，有着独特的二级结构且不编码蛋白质，lncRNAs 可以在核内发挥作用，也可以在细胞质中发挥作用。大量的证据表明，lncRNAs 几乎是每个细胞过程的调节器，其重要性引起了越来越多的人关注。lncRNAs 主要与 mRNA、DNA、蛋白质和 miRNA 相互作用，从而以多种方式在表观遗传、转录、转录后、翻译和翻译后水平调控基因表达。lncRNAs 介导的调控在动物中已经被大量研究，而植物中的 lncRNAs 研究才刚刚起步，近期许多新的研究结果表明，lncRNAs 在植物逆境胁迫、生长发育及系统进化的过程中起了非常重要的作用。概述了 lncRNAs 的来源、分类及 lncRNAs 在植物发育中的调控机制，列举了可用于植物 lncRNAs 分析的主要数据库资源，并就近年来玉米、水稻、小麦等主要农作物 lncRNAs 研究情况进行了梳理和总结，为今后深入挖掘植物lncRNAs 的作用机制及其在农作物中的应用提供一定的参考。 |
| 英文摘要: |
| With the advances in genomics and bioinformatics techniques, particularly high-throughput sequencing technology, many transcriptional units without protein-coding potential have been discovered. Among them, long non-coding RNAs（lncRNAs）are non-coding RNAs that are longer than 200 nt in length, which have unique secondary structures and do not encode proteins. lncRNAs can function in both nuclear and cytoplasmic compartments. A lot of evidence shows that more and more people have put great attention to the importance of lncRNAs as they are regarded as regulators of almost every cellular process. LncRNAs primarily interact with mRNA, DNA, protein, and miRNA and consequently regulate gene expression at the epigenetic, transcriptional, post-transcriptional, translational, and post-translational levels in may ways. LncRNAs-mediated regulation in animals has been extensively studied, while the research on lncRNAs in plants is just beginning. Recently, many new research results have shown that lncRNAs play a very important role in the process of plant stress, growth and system evolution. This article mainly summarizes the source and classification of lncRNAs and the regulatory mechanism of lncRNAs in plant development, and lists the main database resources that can be used for the analysis of plant lncRNAs. In addition, the research situation of lncRNAs in major crops such as corn, rice and wheat are summarized to provide a certain reference for future exploration on the mechanism of plant lncRNAs and its application in crops. |
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