| 张昆丽，李春玲.副猪嗜血杆菌病研究进展[J].广东农业科学,2020,47(12):166-174 |
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副猪嗜血杆菌病研究进展 |
| Research Progress in Haemophilus parasuis Disease |
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| DOI：10.16768/j.issn.1004-874X.2020.12.017 |
| 中文关键词: 副猪嗜血杆菌 致病机制 诊断方法 疫苗 |
| 英文关键词: Haemophilus parasuis pathogenic mechanism diagnostic method vaccine |
| 基金项目:广东省农业科学院科技创新战略专项资金（高水平农科院建设）- 人才项目（R2019YJ-YB2005）；广东省重点领域研发计划项目（2019B020217002）；广东省自然科学基金面上项目（2020A1515010475）；广东省现代农业产业技术体系创新团队项目（2019KJ119） |
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| 中文摘要: |
| 副猪嗜血杆菌病是由副猪嗜血杆菌（Haemophilus parasuis, HPS）感染引起的猪多发性纤维素性浆膜炎、肺炎、关节炎、脑膜炎等全身性炎症。HPS 属于非运动、多形态、有荚膜的革兰氏阴性小杆菌，是猪上呼吸道的条件致病菌。该菌血清型众多，各菌株间毒力差距较大，毒力菌株能感染任何日龄的猪，引起副猪嗜血杆菌病。近年来该病在我国广泛流行，且与多种病毒与细菌混合感染严重，导致猪群发病率和死亡率上升，给我国造成巨大的经济损失，严重影响我国生猪产业的健康发展。介绍了HPS 的病原学特性、流行病学、致病机制与毒力因子，综述了副猪嗜血杆菌病的实验室诊断方法、灭活疫苗、亚单位疫苗和菌影疫苗的研究进展，以期为该病的防控提供参考。 |
| 英文摘要: |
| Haemophilus parasuis（HPS）disease is a systemic inflammation caused by HPS infection in pigs,such as polyserositis, pneumonia, arthritis and meningitis. HPS is a Gram-negative, non-motile, pleomorphic rod-shaped and capsule bacterium, which is a conditional pathogenic bacterium in the upper respiratory tract of pigs. There are many serum types of HPS, and the virulence of each strain varies greatly. The virulence strains can infect any day-old pig and cause HPS disease. In recent years, HPS has been widely prevalent in China, and co-infection with a variety of viruses and bacteria is common. HPS infection has caused high morbidity and mortality of pigs and resulted in huge economic losses, which seriously affected the healthy development of pig industry in China. The etiologic characteristics, epidemiology, pathogenic mechanism and virulence factors of HPS were introduced, and the research progress in HPS laboratory diagnosis and development of vaccines such as inactivated vaccine, subunit vaccine and vaccine of bacterial ghost were summarized in order to provide references . |
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