| 张 璞，陈建凯，赖月辉，林德锐，李复坤，周晓敏，侯高伟，齐冬梅.猪瘟病毒检测和猪瘟疫苗研究进展[J].广东农业科学,2022,49(4):106-115 |
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猪瘟病毒检测和猪瘟疫苗研究进展 |
| Research Progress in Classical Swine Fever Virus Detection and Classical Swine Fever Vaccines |
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| DOI：10.16768/j.issn.1004-874X.2022.04.013 |
| 中文关键词: 猪瘟病毒 抗原检测 抗体检测 猪瘟活疫苗 标记疫苗 亚单位疫苗 载体疫苗 |
| 英文关键词: Classical Swine Fever Virus antigen detection antibody detection Classical Swine Fever live vaccines marker vaccine subunit vaccine vector vaccine |
| 基金项目: |
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| 中文摘要: |
| 猪瘟（Classical Swine Fever，CSF）是由猪瘟病毒（Classical Swine Fever Virus，CSFV）引起的高度
传染性、致死性疾病，是公认对养猪业危害最严重的病毒性疾病之一。自 1810 年首次报告 CSF 疫情至今，CSF
给世界养猪业造成了重大经济损失，持续威胁着全球猪肉生产和人类的食品安全。世界动物卫生组织将 CSF 列
为最重要的法定报告传染病之一，在我国被列为一类传染病。现阶段 CSF 临床表现形式复杂多变，有死亡率很
高的急性型或死亡率变化不定的亚急性型、慢性型、隐性型及持续感染型等，且常与多种疫病混合感染。目前，
疫苗免疫接种仍然是全球大多数国家特别是发展中国家防控 CSF 的主要手段， CSFV 抗原 / 抗体试验室诊断和临
床检测技术的开发和应用对于 CSF 防控也起到非常重要的作用。随着生物技术的快速发展，更多的 CSFV 抗原 /
抗体检测技术和新型疫苗被开发和批准使用。综述 CSFV 抗原和抗体检测技术、CSFV 减毒活疫苗和亚单位疫苗、
载体疫苗等新型疫苗开发进展等，以期为更好地防控 CSF 提供参考。 |
| 英文摘要: |
| Classical Swine Fever (CSF) is a highly infectious and fatal disease caused by Classical Swine Fever Virus
(CSFV). It is recognized as one of the most serious viral diseases in pig industry. Since CSF was first reported in 1810, CSF
has caused significant economic losses to the pig industry in the world and continues to threaten global pork production and
human food security. CSF was listed as one of the most important notifiable infectious diseases by the World Organization
for Animal Health (OIE), and it was listed as “Class I infectious diseases” in China. At present, CSF is clinically manifested
complicated and changeably as acute form with high mortality or subacute type, chronic type, recessive type and continuous
infection type with variable mortality, and often infected combined with various diseases. Vaccination is still one of the main
means to prevent and control CSF in most countries, especially in developing countries. The development and application
of various laboratory diagnostic methods and clinical detection techniques for CSFV antigens and antibodies play a very
important role in the prevention and control of CSF. With the rapid development of biotechnology, more diagnostic techniques and new-type vaccines for CSFV have been developed and approved. CSFV antigen and antibody diagnostic techniques, and the
development and prospects of live attenuated and new-type CSFV vaccines such as subunit and vector vaccines are reviewed in
order to provide references for better prevention and control of CSF. |
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