| 翟 颀，黄敏霞，吕殿红，贾春玲，周秀蓉，温肖会，罗胜军.牛结节性皮肤病病毒基因组学研究进展[J].广东农业科学,2022,49(7):97-104 |
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牛结节性皮肤病病毒基因组学研究进展 |
| Research Progress in Genomics ofLumpy Skin Disease Virus |
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| DOI：10.16768/j.issn.1004-874X.2022.07.013 |
| 中文关键词: 牛结节性皮肤病病毒（LSDV） 病原学 基因组学 测序 重组毒株 |
| 英文关键词: Lumpy Skin Disease Virus（LSDV） etiology genomics sequencing recombinant strain |
| 基金项目:广东省动物疫病野外科学观测研究站项目（2021B1212050021）；广东省现代农业产业技术体系创新团队建设专项（2022KJ119）；广东省农业科学院“十四五”学科团队项目（202122TD）；广东省农业科学院动物卫生研究所创新基金（CX202112） |
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| 中文摘要: |
| 牛结节性皮肤病（Lumpy Skin Disease，LSD）是一种由牛结节性皮肤病病毒（Lumpy Skin Disease
Virus，LSDV）引起牛产生结节特征性病变的动物传染病，在东亚、南亚和东南亚等国家广泛流行，对当地养牛
业造成严重的经济损失。目前我国将 LSD 作为二类动物疫病管理，自 2019 年以来，国内已有 10 多个省份报告
过 LSD 疫情，疫情形势十分严峻。当前分离增殖 LSDV 较优的细胞为牛肾细胞。LSDV 为痘病毒科山羊痘病毒属，
其病毒粒子大小约为 290 nm × 270 nm，具有两种存在形态，病毒基因组复杂庞大，约为 151 kb，包含 150 多个
基因。目前 GenBank 数据库中仅保存有 40 多条 LSDV 病毒株的全基因组序列信息，流行毒株除了 田间野毒株，
近年来在亚洲部分地区还出现了田间野毒株和疫苗毒株的重组毒株，并且流行的重组毒株具有致病性，给未来
LSD 的疫苗研制和防控策略制定提出了新挑战。综述了 LSD 的病原学，以及非洲、欧洲和亚洲不同地区 LSDV
毒株全基因组学的研究进展，以期为 LSD 的防控和深入研究提供参考。 |
| 英文摘要: |
| Lumpy skin disease (LSD) is an animal infectious disease caused by Lumpy Skin Disease Virus (LSDV) that
produces nodular lesions in cattle, and is widespread in East, South and Southeast Asian countries, causing serious economic losses to the local cattle industry. Currently, LSD is managed as a second-class animal disease in China. Since 2019, more than
ten provinces in China have reported LSD epidemics, whose situation is very serious. At present, the superior cell for LSDV
isolation and proliferation is Madin-Darby bovine kidney (MDBK). As a member of the Goat Pox Virus genus of the Poxviridae
family, LSDV has a virus particle diameter about 290 nm × 270 nm, with two existence forms. The viral genome is complex and
huge, about 151 kb, and contains more than 150 genes. Currently, only approximately 40 LSDV strains containing the whole
genome sequence information are stored in the GenBank database. In addition to field wild strains, recombinant strains of field
wild strains and vaccine strains have also emerged in some parts of Asia in recent years, and the prevalent recombinant strains
are pathogenic, which poses new challenges for development of vaccine and preparation of prevention and control strategies for
LSD in the future. The study mainly summarizes the etiology of LSD and the progress in the genome-wide study of LSDV strains
in different regions of Africa, Europe and Asia, with a view to providing references for the prevention and control of LSD and
further researches. |
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